Dear Russ: Welcome. The devil is in the details. Prism uses some kind of special bootstrap trick whereby if you unbalance the output of your Lyra, its output goes up 6 dB and its headroom goes down 6 dB. It’s the same circuit at that point, no additional nor fewer components. I would stick to balanced in that scenario. Only if you reduce the number of components in the chain POTENTIALLY the sound will be more transparent.
Hope this helps,